作者
Stephanie JB Vos, Frans Verhey, Lutz Frölich, Johannes Kornhuber, Jens Wiltfang, Wolfgang Maier, Oliver Peters, Eckart Rüther, Flavio Nobili, Silvia Morbelli, Giovanni B Frisoni, Alexander Drzezga, Mira Didic, Bart NM van Berckel, Andrew Simmons, Hilkka Soininen, Iwona Kłoszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Simon Lovestone, Cristina Muscio, Sanna-Kaisa Herukka, Eric Salmon, Christine Bastin, Anders Wallin, Arto Nordlund, Alexandre De Mendonça, Dina Silva, Isabel Santana, Raquel Lemos, Sebastiaan Engelborghs, Stefan Van der Mussele, Alzheimer’s Disease Neuroimaging Initiative, Yvonne Freund-Levi, Åsa K Wallin, Harald Hampel, Wiesje van der Flier, Philip Scheltens, Pieter Jelle Visser
发表日期
2015/5/1
期刊
Brain
卷号
138
期号
5
页码范围
1327-1338
出版商
Oxford University Press
简介
Three sets of research criteria are available for diagnosis of Alzheimer’s disease in subjects with mild cognitive impairment: the International Working Group-1, International Working Group-2, and National Institute of Aging-Alzheimer Association criteria. We compared the prevalence and prognosis of Alzheimer’s disease at the mild cognitive impairment stage according to these criteria. Subjects with mild cognitive impairment (n = 1607), 766 of whom had both amyloid and neuronal injury markers, were recruited from 13 cohorts. We used cognitive test performance and available biomarkers to classify subjects as prodromal Alzheimer’s disease according to International Working Group-1 and International Working Group-2 criteria and in the high Alzheimer’s disease likelihood group, conflicting biomarker groups (isolated amyloid pathology or suspected non-Alzheimer pathophysiology), and low Alzheimer’s …
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SJB Vos, F Verhey, L Frölich, J Kornhuber, J Wiltfang… - Brain, 2015