作者
Flavio Nobili, Mehrdad Naseri, Fabrizio De Carli, Susan Asenbaum, Jan Booij, Jacques Darcourt, Peter Ell, Özlem Kapucu, Paul Kemp, Claus Varer, Silvia Morbelli, Marco Pagani, Osama Sabri, Klaus Tatsch, Livia Tossici-Bolt, Terez Sera, Tierry Vander Borght, Koen Van Laere, Andrea Varrone
发表日期
2013/4
期刊
European journal of nuclear medicine and molecular imaging
卷号
40
页码范围
565-573
出版商
Springer-Verlag
简介
Purpose
The aim of this study was to assess striatal dopamine transporter (DAT) availability in a large group of normal subjects.
Methods
The study included 122 healthy subjects, aged 18–83 years, recruited in the multicentre ‘ENC-DAT’ study (promoted by the European Association of Nuclear Medicine). Brain single photon emission computed tomography (SPECT) was acquired by means of dual-head cameras 3 h after [123I]FP-CIT administration. Specific to nondisplaceable binding ratios (SBRs) in the basal ganglia were computed using the ‘BasGan’ software, allowing automatic value extraction with partial volume effect correction. Multicentre camera inhomogeneity was taken into account by calibrating values on basal ganglia phantom data. SBR in each caudate nucleus (C) and putamen (P) were the dependent variables in a repeated measures …
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F Nobili, M Naseri, F De Carli, S Asenbaum, J Booij… - European journal of nuclear medicine and molecular …, 2013
F Nobili, M Naseri, F De Carli, S Asenbaum, J Booij… - European Journal of Nuclear Medicine and Molecular …, 2013