作者
Gianmario Sambuceti, Silvia Morbelli, Luca Vanella, Claudia Kusmic, Cecilia Marini, Michela Massollo, Carla Augeri, Mirko Corselli, Chiara Ghersi, Barbara Chiavarina, Luigi F Rodella, Antonio L'abbate, George Drummond, Nader G Abraham, Francesco Frassoni
发表日期
2009/2/1
期刊
Stem Cells
卷号
27
期号
2
页码范围
399-407
出版商
Oxford University Press
简介
Background
Atherosclerosis progression is accelerated in diabetes mellitus (DM) by either direct endothelial damage or reduced availability and function of endothelial progenitor cells (EPCs). Both alterations are related to increased oxidant damage.
Aim
We examined if DM specifically impairs vascular signaling, thereby reducing the recruitment of normal EPCs, and if increases in antioxidant levels by induction of heme oxygenase-1 (HO-1) can reverse this condition.
Methods
Control and diabetic rats were treated with the HO-1 inducer cobalt protoporphyrin (CoPP) once a week for 3 weeks. Eight weeks after the development of diabetes, EPCs harvested from the aorta of syngenic inbred normal rats and labeled with technetium-99m-exametazime were infused via the femoral vein to estimate their blood clearance and aortic recruitment. Circulating …
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G Sambuceti, S Morbelli, L Vanella, C Kusmic, C Marini… - Stem Cells, 2009