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Correlations among dentin permeability, dentin depth, and dentin bonding of Scotchbond, Clearfil New Bond, and Superbond C&B were studied in bovine incisor crown segments. Since the dentin surface was prepared on deeper dentin, the permeability of the dentin increased both in the presence of, and especially after removal of, the smear layer. In general, the deeper the dentin, the lower the bond strengths of Scotchbond, Clearfil New Bond, and Superbond C&B. The higher the dentin permeability, the lower the bond strength of Superbond C&B, but there was no simple relationship in the case of either Scotchbond or Clearfil New Bond. The bond strength of Superbond C&B was much higher than those of Scotchbond or Clearfil New Bond at any depth of dentin. Superbond C&B should be considered as both an enamel- and dentin-bonding agent.