作者
Sudarshini Ramanathan, Stephen W Reddel, Andrew Henderson, John DE Parratt, Michael Barnett, Prudence N Gatt, Vera Merheb, Raani-Yogeeta Anusuiya Kumaran, Karrnan Pathmanandavel, Nese Sinmaz, Mahtab Ghadiri, Con Yiannikas, Steve Vucic, Graeme Stewart, Andrew F Bleasel, David Booth, Victor SC Fung, Russell C Dale, Fabienne Brilot
发表日期
2014/10/29
期刊
Neuroimmunology & Neuroinflammation
卷号
1
期号
4
页码范围
e40
出版商
Lippincott Williams & Wilkins
简介
Objective
We examined a cohort of adults with aquaporin-4 (AQP4) antibody–negative neuromyelitis optica/neuromyelitis optica spectrum disorder (NMO/NMOSD) for antibodies to myelin oligodendrocyte glycoprotein (MOG).
Methods
We performed a flow cytometry cell-based assay using live human lentivirus–transduced cells expressing full-length surface MOG. Serum was tested in 23 AQP4 antibody–negative NMO/NMOSD patients with bilateral and/or recurrent optic neuritis (BON, n = 11), longitudinally extensive transverse myelitis (LETM, n = 10), and sequential BON and LETM (n = 2), as well as in patients with multiple sclerosis (MS, n = 76) and controls (n = 52).
Results
MOG antibodies were detected in 9/23 AQP4 antibody–negative patients with NMO/NMOSD, compared to 1/76 patients with MS and 0/52 controls (p < 0.001). MOG antibodies were detected in 8/11 patients with BON, 0/10 patients with LETM …
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S Ramanathan, SW Reddel, A Henderson, JDE Parratt… - Neuroimmunology & Neuroinflammation, 2014