作者
Babak B Navi, Carla P Sherman, Richard Genova, Ryna Mathias, Kelsey N Lansdale, Natalie M LeMoss, Julia Wolfe, Anna Skakodub, Hooman Kamel, Scott T Tagawa, Ashish Saxena, Allyson J Ocean, Gerald A Soff, Maria T DeSancho, Costantino Iadecola, Mitchell SV Elkind, Ellinor Peerschke, Cenai Zhang, Lisa M DeAngelis
发表日期
2021/7
期刊
Annals of neurology
卷号
90
期号
1
页码范围
159-169
出版商
John Wiley & Sons, Inc.
简介
Objective
The objective of this study was to examine the pathophysiology of ischemic stroke with cancer.
Methods
We conducted a prospective cross‐sectional study from 2016 to 2020 at 2 hospitals. We enrolled 3 groups of 50 adult participants each. The main group included patients with active solid tumor cancer and acute ischemic stroke. The control groups included patients with acute ischemic stroke only or active cancer only. The patients with stroke‐only and patients with cancer‐only were matched to the patients with cancer‐plus‐stroke by age, sex, and cancer type, if applicable. The outcomes were prespecified hematological biomarkers and transcranial Doppler microemboli detection. Hematological biomarkers included markers of coagulation (D‐dimer and thrombin‐antithrombin), platelet function (P‐selectin), and endothelial integrity (thrombomodulin, soluble intercellular adhesion molecule‐1 [sICAM …
学术搜索中的文章
BB Navi, CP Sherman, R Genova, R Mathias… - Annals of neurology, 2021