作者
Claudio Luchini, Jerome Cros, Antonio Pea, Camilla Pilati, Nicola Veronese, Borislav Rusev, Paola Capelli, Andrea Mafficini, Alessia Nottegar, Lodewijk AA Brosens, Michaël Noë, G Johan A Offerhaus, Peter Chianchiano, Giulio Riva, Paola Piccoli, Claudia Parolini, Giuseppe Malleo, Rita T Lawlor, Vincenzo Corbo, Nicola Sperandio, Mattia Barbareschi, Matteo Fassan, Liang Cheng, Laura D Wood, Aldo Scarpa
发表日期
2018/11/1
期刊
Human pathology
卷号
81
页码范围
157-165
出版商
WB Saunders
简介
Undifferentiated carcinoma with osteoclast-like giant cells (UCOGC), a variant of pancreatic ductal adenocarcinoma (PDAC), has a striking genetic similarity to PDAC but a significantly improved overall survival. We hypothesize that this difference could be due to the immune response to the tumor, and as such, we investigated the expression of PD-1, PD-L1, and CD163 in a series of UCOGC. To this aim, 27 pancreatic UCOGCs (11 pure and 16 PDAC-associated), 5 extrapancreatic tumors with osteoclast-like giant cells and 10 pancreatic anaplastic carcinomas were immunostained using antibodies against PD-1, PD-L1, and CD163. In pancreatic UCOGCs, PD-L1 was expressed in neoplastic cells of 17 (63%) of 27 cases, more often in cases with an associated PDAC (P = .04). Expression of PD-L1 was associated with poor prognosis, confirmed by multivariate analysis: patients with PD-L1–positive UCOGCs had …
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C Luchini, J Cros, A Pea, C Pilati, N Veronese, B Rusev… - Human pathology, 2018