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Seaweeds have attracted special interest as good sources of sulphated polysaccharides (SP) for use in pharmaceutical industries and biotechnology. In this study, we evaluated the effects of SP from the red seaweed Gracilaria cornea (Gc‐TSP) in nociceptive and inflammatory models. In mice, Gc‐TSP (3, 9 or 27 mg/kg) significantly reduced nociceptive responses, as measured by the number of writhes, at all tested doses. In a formalin test, Gc‐TSP significantly reduced licking time in both phases of the test at a dose of 27 mg/kg. In a hot‐plate test, the antinociceptive effect was observed only in animals treated with 27 mg/kg of Gc‐TSP, suggesting that the analgesic effect occurs through a central action mechanism at the highest dose. Gc‐TSP (3, 9 or 27 mg/kg) caused only a slight reduction in neutrophil migration in the rat peritoneal cavity. However, lower doses of Gc‐TSP (3 and 9 mg/kg) significantly …