作者
Hyung Woo Choi, Jihoon Kim, Jinhwan Kim, Yonghwi Kim, Hyun Beom Song, Jeong Hun Kim, Kimoon Kim, Won Jong Kim
发表日期
2016/4/26
期刊
ACS nano
卷号
10
期号
4
页码范围
4199-4208
出版商
American Chemical Society
简介
We report herein the design of a light-responsive gatekeeper for smart nitric oxide (NO) delivery. The gatekeeper is composed of a pH-jump reagent as an intermediary of stimulus and a calcium phosphate (CaP) coating as a shielding layer for NO release. The light irradiation and subsequent acid generation are used as triggers for uncapping the gatekeeper and releasing NO. The acids generated from a light-activated pH-jump agent loaded in the mesoporous nanoparticles accelerated the degradation of the CaP-coating layers on the nanoparticles, facilitating the light-responsive NO release from diazeniumdiolate by exposing a NO donor to physiological conditions. Using the combination of the pH-jump reagent and CaP coating, we successfully developed a light-responsive gatekeeper system for spatiotemporal-controlled NO delivery.
引用总数
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