作者
Isabel Cubero-Millán, María-José Ruiz-Ramos, Antonio Molina-Carballo, Sylvia Martínez-Serrano, Luisa Fernández-López, Irene Machado-Casas, Pilar Tortosa-Pinto, Aida Ruiz-López, Juan-de-Dios Luna-del-Castillo, José Uberos, Antonio Muñoz-Hoyos
发表日期
2017/1
期刊
Psychopharmacology
卷号
234
页码范围
267-279
出版商
Springer Berlin Heidelberg
简介
Rationale
Brain-derived neurotrophic factor (BDNF) enhances the growth and maintenance of several monoamine neuronal systems, serves as a neurotransmitter modulator and participates in the mechanisms of neuronal plasticity. Therefore, BDNF is a good candidate for interventions in the pathogenesis and/or treatment response of attention deficit hyperactivity disorder (ADHD).
Objective
We quantified the basal concentration and daily fluctuation of serum BDNF, as well as changes after methylphenidate treatment.
Method
A total of 148 children, 4–5 years old, were classified into groups as follows: ADHD group (n = 107, DSM-IV-TR criteria) and a control group (CG, n = 41). Blood samples were drawn at 2000 and 0900 hours from both groups, and after 4.63 ± 2.3 months of treatment, blood was drawn only from the …
学术搜索中的文章
I Cubero-Millán, MJ Ruiz-Ramos, A Molina-Carballo… - Psychopharmacology, 2017
