作者
Mauro G Carta, Maria Carolina Hardoy, Alessandra Garofalo, Enrica Pisano, Valentina Nonnoi, Gesuina Intilla, Giancarlo Serra, Cinzia Balestrieri, Luchino Chessa, Cristiana Cauli, Maria Eliana Lai, Patrizia Farci
发表日期
2007/12
期刊
Clinical Practice and Epidemiology in Mental Health
卷号
3
页码范围
1-4
出版商
BioMed Central
简介
Background
Mood and anxiety symptoms in chronic hepatitis C (CHC) may be related to the patient awareness of the diagnosis and prognosis, to side effects induced by interferon (IFN)-alpha treatment, as well as to substance abuse. However, the observation of metabolic alterations in patients with CHC has led to hypothesize a direct effect of hepatitis C virus (HCV) on brain function. This study was aimed at elucidating whether CHC is associated with specific anxiety or mood disorders independently of confounding factors.
Methods
Patient cohort: consecutive patients, 135 with CHC and 76 with chronic hepatitis B (CHB). Exclusion criteria: previous treatment with IFN-alpha, co-infection with HCV and hepatitis B virus, infection with human immunodeficiency virus, drug or alcohol abuse, or malignancies. Controls: subjects without evidence of hepatitis …
引用总数
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MG Carta, MC Hardoy, A Garofalo, E Pisano, V Nonnoi… - Clinical Practice and Epidemiology in Mental Health, 2007