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The objective of the study was to determine the efficacy of a ZnO-doped etch and rinse adhesive in decreasing MMPs-mediated collagen degradation at the resin–dentine hybrid layer, and increasing bonding stability.

C-terminal telopeptide concentrations (ICTP) were determined after 24h, 1wk and 4wk in human dentine beams. Dentine was treated: (1) 37% phosphoric acid for 15s (PA), (2) PA-etched dentine infiltrated with Single Bond (SB), (3) PA-etched dentine infiltrated with ZnO doped SB (ZnO particles – 10wt% – were added to the bonding resin) (ZnO–SB), and (4) Clearfil SE Bond primed-dentine was infiltrated with Clearfil SE bonding resin (CSE). Microtensile bond strength (MTBS) was assessed for the different groups at 24h and after 3months. Debonded dentine surfaces were studied by scanning electron microscopy.

MMPs-mediated collagen degradation occurred …