作者
Ilona A Dekkers, Philip R Jansen, Hildo J Lamb
发表日期
2019/6
期刊
Radiology
卷号
291
期号
3
页码范围
763-771
出版商
Radiological Society of North America
简介
Background
Obesity has been associated with increased risk of accelerated cognitive decline and dementia, which suggests underlying neurobiological changes.
Purpose
To investigate the associations between obesity and brain structure (overall and regional brain volumes, and white matter microstructure) assessed at MRI in a sample of the general population.
Materials and Methods
Between March 2014 and January 2018, 12 087 participants (52.8% women [6381 of 12 087]; mean age, 62 years; age range, 45–76 years) in the prospective observational UK Biobank study underwent 3.0-T multiparametric (ie, three-dimensional T1-weighted diffusion tensor …
学术搜索中的文章
IA Dekkers, PR Jansen, HJ Lamb - Radiology, 2019