作者
Xiang-Zhong Liao, Yong-Hui Fu, Jian-Yong Ma, Wen-Gen Zhu, Ping Yuan
发表日期
2020/6
来源
Cardiovascular Drugs and Therapy
卷号
34
页码范围
391-399
出版商
Springer US
简介
Background
The efficacy and safety of non-vitamin K antagonist oral anticoagulants (NOACs) compared with warfarin in patients with atrial fibrillation (AF) and peripheral artery disease (PAD) remain largely unknown. Therefore, we conducted a meta-analysis to explore the effects of NOACs versus warfarin in this population.
Methods
We systematically searched the PubMed and Embase databases, with no linguistic restrictions, until December 2019 for relevant randomized controlled trials (RCTs) and observational studies. A random-effects model using an inverse variance method was selected to pool the risk ratios (RRs) and 95% confidence intervals (CIs).
Results
A total of six studies (three post hoc analyses of RCTs and three cohort studies) were included in this meta-analysis. Among AF patients treated with NOACs and warfarin, individuals with PAD had increased rates of all-cause death (RR = 1.26, 95 …
学术搜索中的文章
XZ Liao, YH Fu, JY Ma, WG Zhu, P Yuan - Cardiovascular Drugs and Therapy, 2020