作者
Jonathan I Silverberg, Paras P Vakharia, Rishi Chopra, Ryan Sacotte, Neha Patel, Supriya Immaneni, Takeisha White, Robert Kantor, Derek Y Hsu
发表日期
2018/7/1
期刊
The Journal of Allergy and Clinical Immunology: In Practice
卷号
6
期号
4
页码范围
1306-1312
出版商
Elsevier
简介
Background
Little is known about adult-onset atopic dermatitis (AD).
Objective
To determine the associations and clinical characteristics of adult-onset AD.
Methods
A prospective study of 356 adults with AD (age ≥18 years) was performed using standardized questionnaires and examination. AD severity was assessed using the Patient-Oriented Eczema Measure, Eczema Area and Severity Index, Scoring Atopic Dermatitis, body surface area, and numeric rating scale for itch and sleeplessness. Latent class analysis was used to determine dominant clinical phenotypes. Multivariate logistic regression was used to determine the relationship between adult-onset AD and distinct phenotypes.
Results
One hundred forty-nine adults (41.9%) reported onset of AD during adulthood, with 87 (24.4%) after the age of 50 years. Adult- versus childhood-onset AD was associated with birthplace outside the United States (χ2, P = .0008 …
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JI Silverberg, PP Vakharia, R Chopra, R Sacotte… - The Journal of Allergy and Clinical Immunology: In …, 2018