作者
Hitokazu Esaki, Patrick M Brunner, Yael Renert-Yuval, Tali Czarnowicki, Thy Huynh, Gary Tran, Sarah Lyon, Giselle Rodriguez, Supriya Immaneni, Donald B Johnson, Bruce Bauer, Judilyn Fuentes-Duculan, Xiuzhong Zheng, Xiangyu Peng, Yeriel D Estrada, Hui Xu, Christina de Guzman Strong, Mayte Suárez-Fariñas, James G Krueger, Amy S Paller, Emma Guttman-Yassky
发表日期
2016/12/1
期刊
Journal of Allergy and Clinical Immunology
卷号
138
期号
6
页码范围
1639-1651
出版商
Mosby
简介
Background
Atopic dermatitis (AD) affects 15% to 25% of children and 4% to 7% of adults. Paradigm-shifting discoveries about AD have been based on adult biomarkers, reflecting decades of disease activity, although 85% of cases begin by 5 years. Blood phenotyping shows only TH2 skewing in patients with early-onset pediatric AD, but alterations in early pediatric skin lesions are unknown, limiting advancement of targeted therapies.
Objective
We sought to characterize the early pediatric AD skin phenotype and its differences from pediatric control subjects and adults with AD.
Methods
Using immunohistochemistry and quantitative real-time PCR, we assessed biopsy specimens from 19 children with AD younger than 5 years within 6 months of disease onset in comparison with adults with AD or psoriasis and pediatric and adult control subjects.
Results
In lesional skin children showed comparable or greater …
学术搜索中的文章
H Esaki, PM Brunner, Y Renert-Yuval, T Czarnowicki… - Journal of Allergy and Clinical Immunology, 2016