作者
Patrick M Brunner, Ariel Israel, Ning Zhang, Alexandra Leonard, Huei-Chi Wen, Thy Huynh, Gary Tran, Sarah Lyon, Giselle Rodriguez, Supriya Immaneni, Annette Wagner, Xiuzhong Zheng, Yeriel D Estrada, Hui Xu, James G Krueger, Amy S Paller, Emma Guttman-Yassky
发表日期
2018/6/1
期刊
Journal of Allergy and Clinical Immunology
卷号
141
期号
6
页码范围
2094-2106
出版商
Mosby
简介
Background
Although atopic dermatitis (AD) often starts in early childhood, detailed tissue profiling of early-onset AD in children is lacking, hindering therapeutic development for this patient population with a particularly high unmet need for better treatments.
Objective
We sought to globally profile the skin of infants with AD compared with that of adults with AD and healthy control subjects.
Methods
We performed microarray, RT-PCR, and fluorescence microscopy studies in infants and young children (<5 years old) with early-onset AD (<6 months disease duration) compared with age-matched control subjects and adults with longstanding AD.
Results
Transcriptomic analyses revealed profound differences between pediatric patients with early-onset versus adult patients with longstanding AD in not only lesional but also nonlesional tissues. Although both patient populations harbored TH2-centered inflammation, pediatric …
学术搜索中的文章
PM Brunner, A Israel, N Zhang, A Leonard, HC Wen… - Journal of Allergy and Clinical Immunology, 2018