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Immunoglobulin E (IgE) and T-helper type 2 (Th2) cytokines mediate many traits of allergic disease. Therefore, understanding regulation of these responses is critical for comprehending disease pathogenesis and for developing effective therapies. Numerous mechanisms regulate IgE and Th2 cytokine production, however, an emerging concept is that E-series prostaglandins (PGEs), shift the immune response towards allergy by promoting production of IgE and a Th2 profile of cytokines (1). PGEs are lipid molecules which regulate diverse processes throughout the body. Low levels of PGEs are constantly produced in most tissues by “constitutive” cyclooxygenases (COX-1), (2). In response to hormonal or inflammatory stimuli, PGEs are also synthesized by “inducible” cyclooxygenases (COX-2), (2). Of particular importance, PGEs are a major product of professional antigen presenting cells such as …