作者
J-P Spano, F Andre, L Morat, L Sabatier, B Besse, C Combadiere, P Deterre, A Martin, J Azorin, D Valeyre, D Khayat, T Le Chevalier, J-C Soria
发表日期
2004/4/1
期刊
Annals of Oncology
卷号
15
期号
4
页码范围
613-617
出版商
Elsevier
简介
Background
The expression of CXCR4 has been implicated in metastatic dissemination in different models of breast cancer and melanoma. In the present study, we evaluated CXCR4 expression in non-small-cell lung cancer (NSCLC) and the relationship between CXCR4 expression and the prognosis of stage I disease.
Patients and methods
Using immunohistochemical analysis, we retrospectively analyzed CXCR4 expression in specimens from 61 patients with completely resected pathologically confirmed stage I NSCLC for whom clinical follow-up data were available.
Results
In the present study, we have shown that: CXCR4 is expressed by tumor cells in stage I NSCLC; CXCR4 is located in the nucleus and/or in the cytoplasm of tumor cells; strong nuclear staining was observed in 17 cases (29.8%); patients whose tumors had CXCR4-positive nuclear staining had a significantly longer duration of survival than …
引用总数
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