作者
Philipp O Valko, Yuri V Gavrilov, Mihoko Yamamoto, Daniela Noaín, Hasini Reddy, Johannes Haybaeck, Serge Weis, Christian R Baumann, Thomas E Scammell
发表日期
2016/6/1
期刊
Sleep
卷号
39
期号
6
页码范围
1249-1252
出版商
Oxford University Press
简介
Study Objectives
Coma and chronic sleepiness are common after traumatic brain injury (TBI). Here, we explored whether injury to arousal-promoting brainstem neurons occurs in patients with fatal TBI.
Methods
Postmortem examination of 8 TBI patients and 10 controls.
Results
Compared to controls, TBI patients had 17% fewer serotonergic neurons in the dorsal raphe nucleus (effect size: 1.25), but the number of serotonergic neurons did not differ in the median raphe nucleus. TBI patients also had 29% fewer noradrenergic neurons in the locus coeruleus (effect size: 0.96). The number of cholinergic neurons in the pedunculopontine and laterodorsal tegmental nuclei (PPT/LDT) was similar in TBI patients and controls.
Conclusions
TBI injures arousal-promoting neurons of the mesopontine tegmentum, but this injury is less severe than …
学术搜索中的文章
PO Valko, YV Gavrilov, M Yamamoto, D Noaín… - Sleep, 2016