作者
Samira Salihovic, Andrea Ganna, Tove Fall, Corey D Broeckling, Jessica E Prenni, Bert van Bavel, P Monica Lind, Erik Ingelsson, Lars Lind
发表日期
2016/3/1
期刊
Environment international
卷号
88
页码范围
60-66
出版商
Pergamon
简介
Background
Dichlorodiphenyldichloroethylene (p,p′-DDE) and hexachlorobenzene (HCB) are organochlorine pesticides with well-known endocrine disrupting properties. Exposure to p,p′-DDE and HCB concerns human populations worldwide and has been linked to metabolic disorders such as obesity and type 2 diabetes, but details about these associations in humans from the general population are largely unknown.
Objectives
We investigated the associations between p,p′-DDE and HCB exposure and global metabolomic profiles in serum samples from 1016 participants from the Swedish population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study.
Methods
HCB and p,p′-DDE levels were determined using gas chromatography coupled to high-resolution mass spectrometry (GC–HRMS). Metabolite levels were determined by using a non-targeted metabolomics …
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S Salihovic, A Ganna, T Fall, CD Broeckling, JE Prenni… - Environment international, 2016