作者
Alberto Julio-Amilpas, Teresa Montiel, Eva Soto-Tinoco, Cristian Gerónimo-Olvera, Lourdes Massieu
发表日期
2015/5
期刊
Journal of Cerebral Blood Flow & Metabolism
卷号
35
期号
5
页码范围
851-860
出版商
SAGE Publications
简介
Glucose is the main energy substrate in brain but in certain circumstances such as prolonged fasting and the suckling period alternative substrates can be used such as the ketone bodies (KB), beta-hydroxybutyrate (BHB), and acetoacetate. It has been shown that KB prevent neuronal death induced during energy limiting conditions and excitotoxicity. The protective effect of KB has been mainly attributed to the improvement of mitochondrial function. In the present study, we have investigated the protective effect of D-BHB against neuronal death induced by severe noncoma hypoglycemia in the rat in vivo and by glucose deprivation (GD) in cortical cultures. Results show that systemic administration of D-BHB reduces reactive oxygen species (ROS) production in distinct cortical areas and subregions of the hippocampus and efficiently prevents neuronal death in the cortex of hypoglycemic animals. In vitro results show …
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A Julio-Amilpas, T Montiel, E Soto-Tinoco… - Journal of Cerebral Blood Flow & Metabolism, 2015