作者
Gabriela Languren, Teresa Montiel, Alberto Julio-Amilpas, Lourdes Massieu
发表日期
2013/10/1
来源
Neurochemistry international
卷号
63
期号
4
页码范围
331-343
出版商
Pergamon
简介
The aim of the present review is to offer a current perspective about the consequences of hypoglycemia and its impact on the diabetic disorder due to the increasing incidence of diabetes around the world. The main consequence of insulin treatment in type 1 diabetic patients is the occurrence of repetitive periods of hypoglycemia and even episodes of severe hypoglycemia leading to coma. In the latter, selective neuronal death is observed in brain vulnerable regions both in humans and animal models, such as the cortex and the hippocampus. Cognitive damage subsequent to hypoglycemic coma has been associated with neuronal death in the hippocampus. The mechanisms implicated in selective damage are not completely understood but many factors have been identified including excitotoxicity, oxidative stress, zinc release, PARP-1 activation and mitochondrial dysfunction. Importantly, the diabetic condition …
学术搜索中的文章
G Languren, T Montiel, A Julio-Amilpas, L Massieu - Neurochemistry international, 2013