作者
KV Ananth, Mohammed Asad, N Prem Kumar, SMB Asdaq, GS Rao
发表日期
2010/1
期刊
Indian journal of pharmaceutical sciences
卷号
72
期号
1
页码范围
122
出版商
Wolters Kluwer--Medknow Publications
简介
The present study was carried out to evaluate the effect of methanol and chloroform extracts of Bauhinia purpurea on experimentally induced excision, incision, burn and dead space wound models in Sprague Dawley rats. Formulations of methanol and chloroform extracts of Bauhinia purpurea were prepared in carbopol and simple ointment base at concentrations of 2.5% and 5% and applied to the wounds. In the excision and burn wound models, animals treated with high doses of methanol and chloroform showed significant reduction in time taken for epithelization and wound contraction (50%) compared to control. A significant increase in breaking strength was found in incision wound model with methanol and chloroform extracts compared to their respective bases. In the dead space wound model, methanol and chloroform extract treatment (100 and 500 mg/kg) orally produced a significant increase in the …
学术搜索中的文章
KV Ananth, M Asad, NP Kumar, SMB Asdaq, GS Rao - Indian journal of pharmaceutical sciences, 2010