作者
Ravindra K Gupta, Michael R Jordan, Binta J Sultan, Andrew Hill, Daniel HJ Davis, John Gregson, Anthony W Sawyer, Raph L Hamers, Nicaise Ndembi, Deenan Pillay, Silvia Bertagnolio
发表日期
2012/10/6
期刊
The Lancet
卷号
380
期号
9849
页码范围
1250-1258
出版商
Elsevier
简介
Background
The emergence and spread of high levels of HIV-1 drug resistance in resource-limited settings where combination antiretroviral treatment has been scaled up could compromise the effectiveness of national HIV treatment programmes. We aimed to estimate changes in the prevalence of HIV-1 drug resistance in treatment-naive individuals with HIV since initiation of rollout in resource-limited settings.
Methods
We did a systematic search for studies and conference abstracts published between January, 2001, and July, 2011, and included additional data from the WHO HIV drug resistance surveillance programme. We assessed the prevalence of drug-resistance mutations in untreated individuals with respect to time since rollout in a series of random-effects meta-regression models.
Findings
Study-level data were available for 26 102 patients from sub-Saharan Africa, Asia, and Latin America. We recorded no …
学术搜索中的文章
RK Gupta, MR Jordan, BJ Sultan, A Hill, DHJ Davis… - The Lancet, 2012