作者
Howard N Hodis, Wendy J Mack, Laurie LaBree, Linda Cashin-Hemphill, Alex Sevanian, Ruth Johnson, Stanley P Azen
发表日期
1995/6/21
期刊
Jama
卷号
273
期号
23
页码范围
1849-1854
出版商
American Medical Association
简介
Objective
—To explore the association of supplementary and dietary vitamin E and C intake with the progression of coronary artery disease.
Design
—A subgroup analysis of the on-trial antioxidant vitamin intake database acquired in the Cholesterol Lowering Atherosclerosis Study, a randomized, placebo-controlled, serial angiographic clinical trial evaluating the risk and benefit of colestipol-niacin on coronary artery disease progression.
Setting
—Community- and university-based cardiac catheterization laboratories.
Subjects
—A total of 156 men aged 40 to 59 years with previous coronary artery bypass graft surgery.
Intervention
—Supplementary and dietary vitamin E and C intake (nonrandomized) in association with cholesterol-lowering diet and either colestipol-niacin or placebo (randomized).
Outcome
—Change per subject in the percentage of vessel diameter obstructed because of stenosis (%S) determined by …
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HN Hodis, WJ Mack, L LaBree, L Cashin-Hemphill… - Jama, 1995