作者
Cheng Han Ng, Snow Yunni Lin, Yip Han Chin, Ming Hui Lee, Nicholas Syn, Xin Lei Goh, Jin Hean Koh, Jingxuan Quek, Darren Jun Hao Tan, Shao Feng Mok, Eunice Tan, Yock Young Dan, Nicholas Chew, Chin Meng Khoo, Mohammad Shadab Siddiqui, Mark Muthiah
发表日期
2022/2/1
来源
Endocrine Practice
卷号
28
期号
2
页码范围
223-230
出版商
Elsevier
简介
Objective
Type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD) are closely related, and antidiabetic medications have been shown to be potential therapeutics in NAFLD. Using a network meta-analysis, we sought to examine the effectiveness of antidiabetic agents for the treatment of NAFLD in patients with type 2 diabetes mellitus.
Methods
Medline and Embase were searched for randomized controlled trials relating to the use of antidiabetic agents, including sodium-glucose transport protein 2 (SGLT2) inhibitors, glucagon-like peptide-1 receptor agonists, and peroxisome proliferator-activated receptor gamma (PPARγ) agonists, biguanides, sulfonylureas and insulin, on NAFLD in patients with diabetes. The p-score was used as a surrogate marker of effectiveness.
Results
A total of 14 articles were included in the analysis. PPARγ agonists were ranked as the best treatment in steatosis reduction …
学术搜索中的文章
CH Ng, SY Lin, YH Chin, MH Lee, N Syn, XL Goh… - Endocrine Practice, 2022