作者
Sunil K Singh, P Ganapati Reddy, K Srinivasa Rao, Braj B Lohray, P Misra, Shaikh A Rajjak, Yeleswarapu K Rao, A Venkateswarlu
发表日期
2004/1/1
期刊
Bioorganic & medicinal chemistry letters
卷号
14
期号
2
页码范围
499-504
出版商
Pergamon
简介
Several chemical modifications in the N1-benzenesulfonamide ring of celecoxib are presented. The series with a hydroxymethyl group adjacent to the sulfonamide was found to be the most potent modification that yielded many compounds selectively active against COX-2 enzyme in vitro.
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SK Singh, PG Reddy, KS Rao, BB Lohray, P Misra… - Bioorganic & medicinal chemistry letters, 2004