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This article aims to explore the possibility of using isothermal titration microcalorimetry (ITC) for the investigation of F127 micellization and to study the effect of temperature and addition of propanediol-1,2 on F127 micellization behavior. From this work, ITC proved efficient to be used as a tool for the determination of the critical micellization concentration (CMC) and the enthalpy of micellization (ΔH_mic) of F127, from which the other thermodynamic parameters were calculated (free energy (ΔG_mic), entropy (ΔS_mic), and heat capacity of micellization (ΔC_p,mic)). The micellization of F127 was confirmed to be a strongly endothermic process with predominance of hydrophobic interactions (TΔS_mic>ΔH_mic) and the correlation of enthalpy and entropy of micelle formation exhibits an excellent linearity. The temperature dependence of F127 micellization was revealed by using ITC, since the CMCs values were, respectively, 0 …