作者
Lisa B VanWagner, Hongyan Ning, Cora E Lewis, Christina M Shay, John Wilkins, J Jeffrey Carr, James G Terry, Donald M Lloyd-Jones, David R Jacobs Jr, Mercedes R Carnethon
发表日期
2014/8/1
期刊
Atherosclerosis
卷号
235
期号
2
页码范围
599-605
出版商
Elsevier
简介
Objective
Non-alcoholic fatty liver disease (NAFLD) is an obesity-related condition associated with cardiovascular mortality. Yet, whether or not NAFLD is independently related to atherosclerosis is unclear. In a population-based cross-sectional sample of middle-aged adults free from liver or heart disease, we tested the hypothesis that NAFLD is associated with subclinical atherosclerosis (coronary artery (CAC) and abdominal aortic calcification (AAC)) independent of obesity.
Methods
Participants from the Coronary Artery Risk Development in Young Adults study with CT quantification of liver fat, CAC and AAC were included (n = 2424). NAFLD was defined as liver attenuation ≤40 Hounsfield Units after exclusion of other causes of liver fat. CAC and AAC presence was defined as Agatston score >0.
Results
Mean participant age was 50.1 ± 3.6 years, (42.7% men, 50.0% black) and BMI was 30.6 ± 7.2 kg/m2. The …
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