作者
Sara Marino, Federico Verzegnassi, Paolo Tamaro, Gabriele Stocco, Fiora Bartoli, Giuliana Decorti, Marco Rabusin
发表日期
2009/12/1
期刊
Pediatric blood & cancer
卷号
53
期号
6
页码范围
984-991
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Background
Glucocorticoids (GCs) play a fundamental role in the treatment of pediatric acute lymphoblastic leukemia (ALL), but therapy with these agents often results in a number of severe side effects. The aim of our study was to evaluate the association between polymorphisms of genes encoding for proteins involved in the pharmacokinetics/pharmacodynamics of these drugs and the occurrence of side effects, in particular infections, in a small population of ALL children.
Procedure
Common polymorphisms of NR3C1, ABCB1, glutathione‐S‐transferase (GST)‐M1, GST‐P1, GST‐T1, and IL‐10 genes were analyzed in 36 pediatric patients with ALL, treated according to the AIEOP‐BMF ALL 2000 study protocol. Toxicities occurring during the induction and reinduction periods were assessed and their association with genotypes was evaluated.
Results
In univariate analysis, the risk of severe infections was …
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