作者
Diane Farrar, Mark Simmonds, Maria Bryant, Trevor A Sheldon, Derek Tuffnell, Su Golder, Debbie A Lawlor
发表日期
2017/6/1
来源
BMJ open
卷号
7
期号
6
页码范围
e015557
出版商
British Medical Journal Publishing Group
简介
Objective
To investigate the effectiveness of different treatments for gestational diabetes mellitus (GDM).
Design
Systematic review, meta-analysis and network meta-analysis.
Methods
Data sources were searched up to July 2016 and included MEDLINE and Embase. Randomised trials comparing treatments for GDM (packages of care (dietary and lifestyle interventions with pharmacological treatments as required), insulin, metformin, glibenclamide (glyburide)) were selected by two authors and double checked for accuracy. Outcomes included large for gestational age, shoulder dystocia, neonatal hypoglycaemia, caesarean section and pre-eclampsia. We pooled data using random-effects meta-analyses and used Bayesian network meta-analysis to compare pharmacological treatments (ie, including treatments not directly compared within a trial).
Results
Forty-two trials were included, the reporting of which was …
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D Farrar, M Simmonds, M Bryant, TA Sheldon… - BMJ open, 2017