作者
Ansel Shao Pin Tang, Kai En Chan, Jingxuan Quek, Jieling Xiao, Phoebe Tay, Margaret Teng, Keng Siang Lee, Snow Yunni Lin, May Zin Myint, Benjamin Tan, Vijay K Sharma, Darren Jun Hao Tan, Wen Hui Lim, Apichat Kaewdech, Daniel Huang, Nicholas WS Chew, Mohammad Shadab Siddiqui, Arun J Sanyal, Mark Muthiah, Cheng Han Ng
发表日期
2022/7
期刊
Clinical and Molecular Hepatology
卷号
28
期号
3
页码范围
483
出版商
Korean Association for the Study of the Liver
简介
Methods
Embase and Medline were searched for articles relating to NAFLD, carotid atherosclerosis, and stroke. Proportional data was analysed using a generalized linear mixed model. Pairwise meta-analysis was conducted to obtain odds ratio or weighted mean difference for comparison between patients with and without NAFLD.
Results
From pooled analysis of 30 studies involving 7,951 patients with NAFLD, 35.02%(95% confidence interval [CI], 27.36–43.53%) had carotid atherosclerosis with an odds ratio of 3.20 (95% CI, 2.37–4.32; P< 0.0001). Pooled analysis of 25,839 patients with NAFLD found the prevalence of stroke to be 5.04%(95% CI, 2.74–9.09%) with an odds ratio of 1.88 (95% CI, 1.23–2.88; P= 0.02) compared to non-NAFLD. The degree of steatosis assessed by ultrasonography in NAFLD was closely associated with risk of carotid atherosclerosis and stroke. Older age significantly increased the …
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