作者
HUGO Pan-Asian SNP Consortium, Mahmood Ameen Abdulla, Ikhlak Ahmed, Anunchai Assawamakin, Jong Bhak, Samir K Brahmachari, Gayvelline C Calacal, Amit Chaurasia, Chien-Hsiun Chen, Jieming Chen, Yuan-Tsong Chen, Jiayou Chu, Eva Maria C Cutiongco-de la Paz, Maria Corazon A De Ungria, Frederick C Delfin, Juli Edo, Suthat Fuchareon, Ho Ghang, Takashi Gojobori, Junsong Han, Sheng-Feng Ho, Boon Peng Hoh, Wei Huang, Hidetoshi Inoko, Pankaj Jha, Timothy A Jinam, Li Jin, Jongsun Jung, Daoroong Kangwanpong, Jatupol Kampuansai, Giulia C Kennedy, Preeti Khurana, Hyung-Lae Kim, Kwangjoong Kim, Sangsoo Kim, Woo-Yeon Kim, Kuchan Kimm, Ryosuke Kimura, Tomohiro Koike, Supasak Kulawonganunchai, Vikrant Kumar, Poh San Lai, Jong-Young Lee, Sunghoon Lee, Edison T Liu, Partha P Majumder, Kiran Kumar Mandapati, Sangkot Marzuki, Wayne Mitchell, Mitali Mukerji, Kenji Naritomi, Chumpol Ngamphiw, Norio Niikawa, Nao Nishida, Bermseok Oh, Sangho Oh, Jun Ohashi, Akira Oka, Rick Ong, Carmencita D Padilla, Prasit Palittapongarnpim, Henry B Perdigon, Maude Elvira Phipps, Eileen Png, Yoshiyuki Sakaki, Jazelyn M Salvador, Yuliana Sandraling, Vinod Scaria, Mark Seielstad, Mohd Ros Sidek, Amit Sinha, Metawee Srikummool, Herawati Sudoyo, Sumio Sugano, Helena Suryadi, Yoshiyuki Suzuki, Kristina A Tabbada, Adrian Tan, Katsushi Tokunaga, Sissades Tongsima, Lilian P Villamor, Eric Wang, Ying Wang, Haifeng Wang, Jer-Yuarn Wu, Huasheng Xiao, Shuhua Xu, Jin Ok Yang, Yin Yao Shugart, Hyang-Sook Yoo, Wentao Yuan, Guoping Zhao, Bin Alwi Zilfalil
发表日期
2009/12/11
期刊
Science
卷号
326
期号
5959
页码范围
1541-1545
出版商
American Association for the Advancement of Science
简介
Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.
引用总数
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HUGO Pan-Asian SNP Consortium, MA Abdulla… - Science, 2009