作者
A Eden Evins, Corinne Cather, Sarah A Pratt, Gladys N Pachas, Susanne S Hoeppner, Donald C Goff, Eric D Achtyes, David Ayer, David A Schoenfeld
发表日期
2014/1/8
期刊
Jama
卷号
311
期号
2
页码范围
145-154
出版商
American Medical Association
简介
Importance
It is estimated that more than half of those with serious mental illness smoke tobacco regularly. Standard courses of pharmacotherapeutic cessation aids improve short-term abstinence, but most who attain abstinence relapse rapidly after discontinuation of pharmacotherapy.
Objective
To determine whether smokers diagnosed with schizophrenia and bipolar disease have higher rates of prolonged tobacco abstinence with maintenance pharmacotherapy than with standard treatment.
Design, Setting, and Participants
Randomized, double-blind, placebo-controlled, parallel-group, relapse-prevention clinical trial conducted in 10 community mental-health centers. Of 247 smokers with schizophrenia or bipolar disease recruited from March 2008-April 2012, 203 received 12-weeks’ open-label varenicline and cognitive behavioral therapy and 87 met abstinence criteria to enter the relapse prevention intervention …
学术搜索中的文章
AE Evins, C Cather, SA Pratt, GN Pachas… - Jama, 2014