作者
Marcel W Coolen, Clare Stirzaker, Jenny Z Song, Aaron L Statham, Zena Kassir, Carlos S Moreno, Andrew N Young, Vijay Varma, Terence P Speed, Mark Cowley, Paul Lacaze, Warren Kaplan, Mark D Robinson, Susan J Clark
发表日期
2010/3
期刊
Nature cell biology
卷号
12
期号
3
页码范围
235-246
出版商
Nature Publishing Group UK
简介
Silencing of individual genes can occur by genetic and epigenetic processes during carcinogenesis, but the underlying mechanisms remain unclear. By creating an integrated prostate cancer epigenome map using tiling arrays, we show that contiguous regions of gene suppression commonly occur through long-range epigenetic silencing (LRES). We identified 47 LRES regions in prostate cancer, typically spanning about 2 Mb and harbouring approximately 12 genes, with a prevalence of tumour suppressor and miRNA genes. Our data reveal that LRES is associated with regional histone deacetylation combined with subdomains of different epigenetic remodelling patterns, which include re-enforcement, gain or exchange of repressive histone, and DNA methylation marks. The transcriptional and epigenetic state of genes in normal prostate epithelial and human embryonic stem cells can play a critical part in …
学术搜索中的文章
MW Coolen, C Stirzaker, JZ Song, AL Statham, Z Kassir… - Nature cell biology, 2010