作者
Ashita Barthur, Christine Brezden-Masley, Kim A Connelly, Vinita Dhir, Kelvin KW Chan, Rashida Haq, Anish Kirpalani, Joseph J Barfett, Laura Jimenez-Juan, Gauri R Karur, Djeven P Deva, Andrew T Yan
发表日期
2016/12/5
期刊
Journal of Cardiovascular Magnetic Resonance
卷号
19
期号
1
页码范围
44
出版商
Elsevier
简介
Background
There are limited data on the effects of trastuzumab on the right ventricle (RV). Therefore, we sought to evaluate the temporal changes in right ventricular (RV) structure and function as measured by cardiovascular magnetic resonance (CMR), and their relationship with left ventricular (LV) structure and function in breast cancer patients treated with trastuzumab.
Methods
Prospective, longitudinal, observational study involving 41 women with HER2+ breast cancer who underwent serial CMR at baseline, 6, 12, and 18 months after initiation of trastuzumab. A single blinded observer measured RV parameters on de-identified CMRs in a random order. Linear mixed models were used to investigate temporal changes in RV parameters.
Results
Of the 41 women (age 52 ± 11 years), only one patient experienced trastuzumab-induced cardiotoxicity. Compared to baseline, there were small but significant increases …
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A Barthur, C Brezden-Masley, KA Connelly, V Dhir… - Journal of Cardiovascular Magnetic Resonance, 2016