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Secondary end points were nonsustained VT in 15 patients (18.3%), sustained VT in 1 patient (1.2%), bradycardia in 2 patients (2.4%), heart failure in 2 patients (2.4%), and heart failure–related cardiac death in 1 patient (1.2%). The risk of nonsustained VT increased with the presence of LGE (HR, 6.75; 95% CI, 1.90–24.02; P= 0.003) but did not increase significantly with the extent of LGE (HR, 1.15/5% increase in LGE; 95% CI, 0.94–1.41; P= 0.17). The risk of sustained VT, bradycardia, heart failure, and cardiac death did not increase significantly with the presence or extent of LGE, although analysis was limited by low numbers of individual events. The main findings of this study are that the presence and extent of LGE are associated with a greater risk of adverse cardiac events in FD. LGE has been shown to represent replacement fibrosis in FD and is an accepted substrate for arrhythmia, supporting the biological …