作者
Hilde Van Den Brink, Anna Kopczak, Tine Arts, Laurien Onkenhout, Jeroen CW Siero, Jaco JM Zwanenburg, Marco Duering, Gordon W Blair, Fergus N Doubal, Michael S Stringer, Michael J Thrippleton, Hugo J Kuijf, Alberto De Luca, Jeroen Hendrikse, Joanna M Wardlaw, Martin Dichgans, Geert Jan Biessels
发表日期
2021/1/1
期刊
Cerebral Circulation-Cognition and Behavior
卷号
2
页码范围
100013
出版商
Elsevier
简介
Background
Cerebral small vessel diseases (SVDs) are a major cause of stroke and dementia. Yet, specific treatment strategies are lacking in part because of a limited understanding of the underlying disease processes. There is therefore an urgent need to study SVDs at their core, the small vessels themselves.
Objective
This paper presents the rationale and design of the ZOOM@SVDs study, which aims to establish measures of cerebral small vessel dysfunction on 7T MRI as novel disease markers of SVDs.
Methods
ZOOM@SVDs is a prospective observational cohort study with two years follow-up. ZOOM@SVDs recruits participants with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL, N = 20), sporadic SVDs (N = 60), and healthy controls (N = 40). Participants undergo 7T brain MRI to assess different aspects of small vessel function including small vessel …
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H Van Den Brink, A Kopczak, T Arts, L Onkenhout… - Cerebral Circulation-Cognition and Behavior, 2021