作者
Massimiliano Calabrese, Marco Castellaro, Alessandra Bertoldo, Alberto De Luca, FB Pizzini, GIUSEPPE KENNETH Ricciardi, Marco Pitteri, S Zimatore, Roberta Magliozzi, MD Benedetti, P Manganotti, Stefania Montemezzi, R Reynolds, Alberto Gajofatto, Salvatore Monaco
发表日期
2017/3
期刊
Multiple Sclerosis Journal
卷号
23
期号
3
页码范围
473-482
出版商
SAGE Publications
简介
Background
Although temporal lobe pathology may explain some of the symptoms of multiple sclerosis (MS), its role in the pathogenesis of seizures has not been clarified yet.
Objectives
To investigate the role of temporal lobe damage in MS patients suffering from epilepsy, by the application of advanced multimodal 3T magnetic resonance imaging (MRI) analysis.
Methods
A total of 23 relapsing remitting MS patients who had epileptic seizures (RRMS/E) and 23 disease duration matched RRMS patients without any history of seizures were enrolled. Each patient underwent advanced 3T MRI protocol specifically conceived to evaluate grey matter (GM) damage. This includes grey matter lesions (GMLs) identification, evaluation of regional cortical thickness and indices derived from the Neurite Orientation Dispersion and Density Imaging model.
Results
Regional analysis revealed that in RRMS/E, the regions most affected …
学术搜索中的文章
M Calabrese, M Castellaro, A Bertoldo, A De Luca… - Multiple Sclerosis Journal, 2017