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A mathematical model based upon histological findings of cell cluster distributions in primary breast cancers and lymph node metastases was developed. The model is unique because it accounts for tumor cell cluster formations within both primary tumors and metastases. The importance of inter-cell cluster cross-fire radiation dose for β-emitting radionuclides of different energies was studied. The cell clusters were simulated as spheres with 15, 25 and 50 µm radii having a homogeneous radioactivity distribution. The self-dose as well as the dose distribution around the spheres was calculated for seven radionuclides, 90 Y, 188 Re, 32 P, 186 Re, 159 Gd, 131 I and 177 Lu using the GEANT4 Monte Carlo code. Generally, the self-dose was decreasing with increasing energy of the emitted beta particles. An exception was 188 Re which, compared to 32 P, had higher beta energy as well as higher self-dose. This was …