作者
Caroline Dallaire-Théroux, Brandy L Callahan, Olivier Potvin, Stéphan Saikali, Simon Duchesne
发表日期
2017/1/1
来源
Journal of Alzheimer's Disease
卷号
57
期号
2
页码范围
575-601
出版商
IOS Press
简介
Background: The standard method of ascertaining Alzheimer’s disease (AD) remains postmortem assessment of amyloid plaques and neurofibrillary degeneration. Vascular pathology, Lewy bodies, TDP-43, and hippocampal sclerosis are frequent comorbidities. There is therefore a need for biomarkers that can assess these etiologies and provide a diagnosis in vivo.
Objective: We conducted a systematic review of published radiological-pathological correlation studies to determine the relationship between antemortem magnetic resonance imaging (MRI) and neuropathological findings in AD.
Methods: We explored PubMed in June-July 2015 using “Alzheimer’s disease” and combinations of radiological and pathological terms. After exclusion following screening and full-text assessment of the 552 extracted manuscripts, three others were added from their reference list. In the end, we report results based on 27 …
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C Dallaire-Théroux, BL Callahan, O Potvin, S Saikali… - Journal of Alzheimer's Disease, 2017