作者
Yashwitha Sai Pulakurthi, John M Pederson, Kavitha Saravu, Nitin Gupta, Prasanth Balasubramanian, Shelby Kamrowski, Megan Schmidt, Charan Thej Reddy Vegivinti, Mahmoud Dibas, Natalie L Reierson, Sailaja Pisipati, Betsy Ann Joseph, Pragadeesh Thamarai Selvan, Adam A Dmytriw, Praneeth Reddy Keesari, Varsha Sriram, Spandana Chittajallu, Waleed Brinjikji, Rewanth R Katamreddy, Richa Chibbar, Amber R Davis, Manashree Malpe, Hemant K Mishra, Kevin M Kallmes, Ameer E Hassan, Kirk W Evanson
发表日期
2021/5/21
来源
Medicine
卷号
100
期号
20
页码范围
e25719
出版商
LWW
简介
Background:
Corticosteroid treatment is an effective and common therapeutic strategy for various inflammatory lung pathologies and may be an effective treatment for coronavirus disease 2019 (COVID-19). The purpose of this systematic review and meta-analysis of current literature was to investigate the clinical outcomes associated with corticosteroid treatment of COVID-19.
Methods:
We systematically searched PubMed, medRxiv, Web of Science, and Scopus databases through March 10, 2021 to identify randomized controlled trials (RCTs) that evaluated the effects of corticosteroid therapies for COVID-19 treatment. Outcomes of interest were mortality, need for mechanical ventilation, serious adverse events (SAEs), and superinfection.
Results:
A total of 7737 patients from 8 RCTs were included in the quantitative meta-analysis, of which 2795 (36.1%) patients received corticosteroids plus standard of care (SOC …
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YS Pulakurthi, JM Pederson, K Saravu, N Gupta… - Medicine, 2021