作者
Tendai Samkange, Sarah D'Souza, Kenechukwu Obikeze, Admire Dube
发表日期
2019/10
期刊
Journal of Pharmacy and Pharmacology
卷号
71
期号
10
页码范围
1497-1507
出版商
Oxford University Press
简介
Objective
To evaluate the impact of PEG content on poly(lactic-co-glycolic acid) (PLGA) NP physicochemical properties, hydrophobic drug release (rifampicin as a model drug) and human serum protein binding.
Methods
Rifampicin loaded and unloaded nanoparticles with PEG content of 0–17% (w/w) were prepared by an emulsification–evaporation technique. Nanoparticles were characterized for size, zeta potential and morphology. PEGlyation was confirmed using proton nuclear magnetic resonance (1H NMR). Fluorescence spectroscopy and dynamic light scattering were used to determine nanoparticle-protein binding, binding constants and stability of nanoparticles in human serum, respectively. Drug loading and release were determined by UV-VIS spectroscopy and drug release data was mathematically modelled.
Key findings
A NP PEG content of …
学术搜索中的文章
T Samkange, S D'Souza, K Obikeze, A Dube - Journal of Pharmacy and Pharmacology, 2019