作者
Danijela Gnjidic, Sarah N Hilmer, Fiona M Blyth, Vasi Naganathan, Louise Waite, Markus J Seibel, Andrew J McLachlan, Robert G Cumming, David J Handelsman, David G Le Couteur
发表日期
2012/9/1
期刊
Journal of clinical epidemiology
卷号
65
期号
9
页码范围
989-995
出版商
Pergamon
简介
OBJECTIVE
This study aimed to determine an optimal discriminating number of concomitant medications associated with geriatric syndromes, functional outcomes, and mortality in community-dwelling older men.
STUDY DESIGN AND SETTING
Older men aged ≥70 years (n=1,705), enrolled in the Concord Health and Aging in Men Project were studied. Receiver operating characteristic curve analysis using the Youden Index and the area under the curve was performed to determine discriminating number of medications in relation to each outcome.
RESULTS
The highest value of the Youden Index for frailty was obtained for a cutoff point of 6.5 medications compared with a cutoff of 5.5 for disability and 3.5 for cognitive impairment. For mortality and incident falls, the highest value of Youden Index was obtained for a cutoff of 4.5 medications. For every one increase in number of medications, the adjusted odds ratios …
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D Gnjidic, SN Hilmer, FM Blyth, V Naganathan, L Waite… - Journal of clinical epidemiology, 2012