作者
Wenxia Chai, Johannes Hofland, Pieter M Jansen, Ingrid M Garrelds, René de Vries, Antoon J van den Bogaerdt, Richard A Feelders, Frank H de Jong, AH Jan Danser
发表日期
2010/5/1
期刊
Journal of hypertension
卷号
28
期号
5
页码范围
1044-1053
出版商
LWW
简介
Objective
To test whether glucocorticoids act as the endogenous agonist of cardiac mineralocorticoid receptors, we evaluated the cardiac effects of aldosterone and corticosterone and cardiac steroidogenesis vs. steroid uptake from plasma.
Methods and results
Both corticosterone and aldosterone increased left ventricular pressure in the rat heart. Aldosterone decreased coronary flow, whereas corticosterone increased it. All corticosterone effects were blocked by the glucocorticoid receptor antagonist, RU486, and unaltered by the mineralocorticoid receptor antagonist, canrenoate, or the 11β-hydroxysteroid dehydrogenase (HSD11B) 2 inhibitor, carbenoxolone. Unlike mineralocorticoid receptor blockade, RU486 did not ameliorate postischemia infarct size and arrhythmias. Corticosterone, when added to the perfusion buffer, rapidly accumulated at cardiac tissue sites, reaching steady-state levels that were identical to …
引用总数
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