作者
Douglas D Fraser, Lori A MudrickDonnon, Brian A Macvicar
发表日期
1994/6
来源
Glia
卷号
11
期号
2
页码范围
83-93
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
GABA receptors are distributed widely throughout the central nervous system on a variety of cell types. It has become increasingly clear that astrocytes, both in cell culture and tissue slices, express abundant GABAA receptors. In astrocytes, GABA activates Clspecific channels that are modulated by barbiturates and benzodiazepines; however, the neuronal inverse agonist methyl4ethyl6, 7dimethoxy螃漫carboline3carboxylate enhances the current in a subpopulation of astrocytes. The properties of astrocytic GABAA receptors, therefore, are remarkably similar to their neuronal counterparts, with only a few pharmacological exceptions. In stellate glial cells of the pituitary pars intermedia, GABA released from neuronal terminals activates postsynaptic potentials directly. The physiological significance of astrocytic GABAAreceptor activation remains unknown, but it may be involved in extracellular ion …
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学术搜索中的文章
DD Fraser, LA MudrickDonnon, BA Macvicar - Glia, 1994