作者
Ioanna Giopanou, Nikolaos I Kanellakis, Anastasios D Giannou, Ioannis Lilis, Antonia Marazioti, Magda Spella, Vassilios Papaleonidopoulos, Davina CM Simoes, Dimitra E Zazara, Theodora Agalioti, Charalampos Moschos, Sophia Magkouta, Ioannis Kalomenidis, Vily Panoutsakopoulou, Anne-Sophie Lamort, Georgios T Stathopoulos, Ioannis Psallidas
发表日期
2020/8/12
期刊
Carcinogenesis
卷号
41
期号
8
页码范围
1134-1144
出版商
Oxford University Press
简介
Increased expression of osteopontin (secreted phosphoprotein 1, SPP1) is associated with aggressive human lung adenocarcinoma (LADC), but its function remains unknown. Our aim was to determine the role of SPP1 in smoking-induced LADC. We combined mouse models of tobacco carcinogen-induced LADC, of deficiency of endogenous Spp1 alleles, and of adoptive pulmonary macrophage reconstitution to map the expression of SPP1 and its receptors and determine its impact during carcinogenesis. Co-expression of Spp1 and mutant KrasG12C in benign cells was employed to investigate SPP1/KRAS interactions in oncogenesis. Finally, intratracheal adenovirus encoding Cre recombinase was delivered to LSL.KRASG12D mice lacking endogenous or overexpressing transgenic Spp1 alleles. SPP1 was overexpressed in experimental and human LADC and portended poor survival. In response to two …
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I Giopanou, NI Kanellakis, AD Giannou, I Lilis… - Carcinogenesis, 2020