作者
Anagnostopoulos Gerasimos, Motiño Omar, Sijing Li, Vincent Carbonnier, Hui Chen, Sica Valentina, Durand Sylvère, Bourgin Mélanie, Aprahamian Fanny, Nirmalathasan Nitharsshini, Donne Romain, Desdouets Chantal, Marcelo Simon Sola, Kotta Konstantina, Montégut Léa, Lambertucci Flavia, Surdez Didier, Sandrine Grossetête, Delattre Olivier, Maria Chiara Maiuri, Isabelle Martins, Kroemer Guido
发表日期
2022/4/1
期刊
Cell Death and Disease
卷号
13
期号
4
出版商
Springer Nature BV
简介
Acyl-coenzyme-A-binding protein (ACBP), also known as a diazepam-binding inhibitor (DBI), is a potent stimulator of appetite and lipogenesis. Bioinformatic analyses combined with systematic screens revealed that peroxisome proliferator-activated receptor gamma (PPARγ) is the transcription factor that best explains the ACBP/DBI upregulation in metabolically active organs including the liver and adipose tissue. The PPARγ agonist rosiglitazone-induced ACBP/DBI upregulation, as well as weight gain, that could be prevented by knockout of Acbp/Dbi in mice. Moreover, liver-specific knockdown of Pparg prevented the high-fat diet (HFD)-induced upregulation of circulating ACBP/DBI levels and reduced body weight gain. Conversely, knockout of Acbp/Dbi prevented the HFD-induced upregulation of PPARγ. Notably, a single amino acid substitution (F77I) in the γ2 subunit of gamma-aminobutyric acid A receptor …
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A Gerasimos, M Omar, S Li, V Carbonnier, H Chen… - Cell Death and Disease, 2022