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Staphylococcus aureus and coagulase-negative staphylococci (CNS) are recognized as causing nosocomial and community-acquired infections in every region of the world. The resistance to antimicrobial agents among staphylococci is an increasing problem. Clindamycin (CL) is considered to be one of the alternative agents in these infections. This study demonstrates a simple, reliable method (double-disc diffusion test) for detecting inducible resistance to CL in erythromycin-resistance (ER-R) isolates of S. aureus and CNS. A total of 883 (52.3 %) isolates of S. aureus and 804 (47.7 %) isolates of CNS were selected from recent (2003–2005) clinical isolates recovered in the laboratory of the authors; duplicate isolates were not included. A total of 214 (12.6 %) S. aureus and 308 (18.3 %) CNS isolates were selected based on ER-R and CL sensitivity using standard National Committee for Clinical Laboratory …